How Florfenicol Injection Works?

November 25,2022

When people get sick, animals also get sick. For example, the most common disease in pigs is a respiratory disease, while the chicken is mainly susceptible to Pasteurella disease. The onset of animals is relatively urgent, it is not easy to find, and it is highly contagious. Once there is a bacterial infection, it must be controlled and treated as soon as possible to prevent large-scale deaths and cause greater losses. If the animal has a bacterial infection, it can be treated with a Florfenicol injection. Let's introduce the role of florfenicol injection.


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Pharmacological effect


Pharmacodynamics Florfenicol belongs to the broad-spectrum antibacterial drugs of amido alcohols and has strong antibacterial activity against a variety of Gram-positive bacteria, Gram-negative bacteria, and mycoplasma. Florfenicol is primarily a bacteriostatic agent that inhibits bacterial protein synthesis by binding to the ribosomal 50S subunit. The antibacterial activity of florfenicol against many microorganisms in vitro is similar to or stronger than that of chloramphenicol and thiamphenicol, and some bacteria resistant to chloramphenicol due to acetylation, such as Escherichia coli, Klebsiella pneumonia, etc. Sensitivity to florfenicol is still possible. Pasteurella hemolytic, Pasteurella multocida, and Actinobacillus pleuropneumoniae were highly sensitive to florfenicol.


Pharmacokinetics Intramuscular injection of florfenicol is rapidly absorbed, and the therapeutic concentration can be reached in the blood after about 1 hour, and the peak plasma concentration can be reached in 1-3 hours. The bioavailability is over 80%. Florfenicol is widely distributed in animals and can penetrate the blood-brain barrier. The main drug is excreted in the urine, and a small amount is excreted in feces.




For bacterial diseases of cattle, sheep, pigs, dogs, cats, chickens, and fish caused by sensitive bacteria. It can quickly relieve the symptoms of dyspnea, cough, asthma, throat swelling, purple skin, loss of appetite, lethargy, persistent high fever, and other symptoms of livestock and poultry. Clinically used for the treatment of:


1. Porcine respiratory diseases: porcine infectious pleuropneumonia, paratyphoid fever, porcine pneumonia, atrophic rhinitis, Haemophilus parasuis disease, asthma, etc.


2. Chicken hemolytic pasteurellosis, duck infectious serositis, poultry colibacillosis, poultry multocida pasteurellosis, Haemophilus paragallinia, etc.


3. Respiratory and systemic infections caused by deer, cattle, eine Pasteurella, Escherichia coli, Salmonella, actinomycetes, and other pathogens.