Pharmacological Effects Of Kananmycin Sulfare Injection

Kananmycin sulfare injection is a commonly used veterinary drug. In this paper, we will introduce it pharmacological effects and what disease it can treat.

What Is Kananmycin Sulfare Injection?

Kanamycin is a protein biosynthesis inhibitor. Bacteria can become resistant if they produce an enzyme that destroys kanamycin. Kanamycin antiplasmid is often used as a selection gene or marker gene in molecular cloning. Can be used for oral and intravenous injection, effective against a variety of bacterial infections, isolated from Streptomyces kanamycin.

Some strains of Escherichia coli, Klebsiella, Enterobacter, Proteus, Tuberculosis and Staphylococcus aureus are sensitive to kanamycin. Pseudomonas aeruginosa, gram-positive bacteria (except Staphylococcus aureus), anaerobic bacteria, Mycobacterium atypical, Rickettsiae, fungi and viruses are resistant to kanamycin. There was some cross-resistance between kanamycin and other aminoglycoside drugs.

It has strong antibacterial activity to skin and soft tissue, digestive tract, respiratory tract, urogenital tract and many kinds of gram-negative and positive bacterial infections. It is mainly used for enteritis, peritonitis, perihepatic inflammation, salpingitis, pneumonitis and pullorosis caused by bacteria such as Escherichia coli, rimeria anatipestilence, salmonella and so on.

Adverse Reactions

• Kanamycin and streptomycin have ototoxicity, and stronger than streptomycin, gentamicin.
• Kanamycin is also nephrotoxic, but vestibular toxicity is less common. Kanamycin is less toxic than neomycin.
• Cats are sensitive to kanamycin, which can cause nausea, vomiting, salivation and ataxia at normal doses.
• Neuromuscular blockade is often caused by excessive doses of kanamycin. Accidental death often occurs in dogs and cats after surgical general anesthesia, when combined with penicillin and kanamycin to prevent infection, due to the enhanced effect of general anesthesia and muscle relaxants on neuromuscular block.

Precautions

• Kanamycin and other aminoglycoside kind have cross allergy phenomenon, to aminoglycoside kind allergic disease animal is forbidden.
• It should be used with caution when dehydration (which can lead to increased blood concentration) or renal impairment occurs in diseased animals.
• In the treatment of urinary tract infections, both carnivores and omnivores can take sodium bicarbonate orally to make urine alkaline to enhance the effect.

Effect Of Kananmycin Sulfare Injection On Pig Asthma

Swine asthma, also known as swine endemic pneumonia, is a chronic lung disease in pigs, the main symptoms are cough, asthma.

Regardless of individual, age, breed, all can infect this disease. Lactation and young pigs are most susceptible to the disease, followed by sows and lactating sows in late pregnancy, and fattening pigs are generally chronically infected. The main route of infection was respiratory tract infection in pigs. This disease has no obvious seasonality, but it occurs in winter and spring and in changing seasons. In addition, damp, high density, poor ventilation and other factors are also easily induced. At present, the incidence of this disease is high, the symptoms are not obvious, and the fatality rate is low. In practice, most deaths occur as a result of secondary infection with other respiratory diseases.

The main symptoms are cough and asthma, but body temperature and appetite are generally normal. The the pigs have been ill for a long time, they will be indolence, thin, coarse hair disorderly, slow growth, increase in the ratio of feed to meat.

Prevention And Control Measures

• At the same time of strengthening the daily management, the swine asthma virus vaccine in the epidemic area (farm) was inoculated, male and sow were inoculated twice a year, 15-18 days old were inoculated once.
• Kanamycin sulfate is intramuscularly injected, 30,000 to 50,000 units/kg body weight, twice a day.

In Conclusion

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