2.5% Albendazole Oral Suspension

[Pharmacology]

 (1) Pharmacodynamics  Albendazole is the most widely used benzimidazole insecticide in veterinary clinic . It is not only highly effective on many kinds of nematodes, but also has strong repellent effect on some trematodes and tapeworms. The mechanism of albendazole can be referred to thiabendazole and mebendazole.

（2) Pharmacokinetics   Most benzimidazoles have low solubility, so the amount of drugs absorbed by gastrointestinal tract is very limited. However, albendazole is the best absorption of benzimidazole insecticides. After absorption, the drug can reach the peak in blood within 2-4 hours and last for 15-24 hours.

[Usage and Dosage] take orally 0.2-0.4ml / kg horse, 0.4-0.6ml / kg sheep, 0.2-0.4ml / kg pig, 1-2ml / kg dog, 4-8ml / kg poultry

[Indications] (1) albendazole has a good effect on most of the gastrointestinal parasites of cattle, especially on the adults and larvae of Trichostrongylus evansi, Trichostrongylus serpentiforme, Cupressus tumefaciens, anostoma bovis, oerster's nematode, Strongylus papilloides and Haemonchus contortus. At high dose limit, not only the larvae of most of the above species could be almost eliminated, but also the adults of radiation esophagostoma, tenuiform, reticulum, Moniezia, Fasciola hepatica and Fasciola Magna could be cured. This product usually has good effect on immature worms in the true stomach and small intestine, but very poor effect on immature worms in the cecum and large intestine, and Fasciola hepatica. Albendazole had very poor or almost no effect on Trichogramma bovis, filariae Digitaria, Fasciola anterior and posterior, platysma pancreatica and Fasciola bison.

（2) Low dose of sheep had good repellent effect on Haemonchus elegans, Oster's nematode, Trichostrongylus, Meloidogyne tenuipes, Geiger's nematode, oesophagus, charbert's nematode, Marshall's nematode, Cupressus and most species of larvae (except Marshall's and Cupressus). Low dose was also effective on adult worms of reticulum, immature worms and monitz tapeworm. The results showed that the high dose had obvious repellent effect on the adults of Taenia radiata, Fasciola hepatica, Fasciola magna and diplocentrum lanceolate. Albendazole had very poor effect on immature body of Fasciola hepatica.

（3) The results showed that the low dose of pig had excellent effect on Ascaris lumbricoides, oesophagus dentatus and cystocephalus hexapterus www.med126.com However, the effect on P. cellulosae is not ideal. It has been proved that 30-40 mg / kg mixed feeding for 5 days can also completely cure the disease. The effect of albendazole on echinocephalus vermiculiformis was not stable; It has no effect on Fasciola brucelli, pseudonudus krylovii and cysticercus tenuiformis.

（4) The results showed that the recommended dose could only be used for the adult of Taenia quadriceps and Taenia echinococci. The anthelmintic rate of Ascaris lumbricoides was about 90%. The results showed that it was very poor to the adult of heterorhabdus gallinarum, Capillaria lanatus and labial uncinate. The effect of albendazole on Taenia saginata and Echinostoma was 100% at the dose of 25 mg / kg, and it was highly effective on Meloidogyne geese and Echinostoma when the dose was as high as 50 mg / kg.

（5) Dogs suffering from Ascaris canis or ancylostomiasis canis must take 50 mg / kg daily for three days. The above dosage was also effective for 5 days.

（6) In cats and rabbits infected with Paragonimus krylovii, 100 mg / kg of Paragonimus krylovii was given twice a day for 14 days. Rabbits artificially infected with Cysticercus lentiformis can be cured by 15 mg / kg for 5 days.

（7) Horses are highly effective against large round nematodes of horses, such as common round nematode, round nematode edentulous, round nematode of horses and most of the adults and larvae of small round nematode of horses. However, albendazole was not effective against Taenia equina.